Symposien Donnerstag

Änderungen im Programmablauf vorbehalten.

Saal A&B 08:00 - 09:30 01.10.2015
Symposium Do02
AMD Translational Research - From Histology to Treatment
Vorsitzende/r: Martin Rudolf (Lübeck), Christine A. Curcio (Birmingham)

The aim of the symposium is to connect current basic with clinical research and vice versa with a focus on age-related macular degeneration. The topics include AMD pathohistology with clinical implications, new OCT findings, and merging new AMD treatment options beyond established antiVEGF-therapy.
Referent/in: Thomas Ach (Würzburg)
The human retinal pigment epithelium (RPE) accumulates fluorescent granules (lipofuscin, melanolipofuscin) throughout life. As shown in in vivo fundus autofluorescence (AF), the RPE-AF intensity increases with age, but decreases after the age 70 (PMID: 11431454). Recent RPE-flatmount imaging studies indicate that on a subcellular level: i) distribution of fluorescent granules is regular and organized in normal aging (PMID: 25034602), ii) cells re-organize and might lose individual granules with advanced age. In AMD, granule re-organization (granule aggregations (5-20µm in diameter) and shedding is enforced (PMID: 25758814).
Referent/in: Christine A. Curcio (Birmingham)
The compartmentalization of light scattering organelles in photoreceptors and retinal pigment epithelium (RPE) makes it possible to assign the four outer retinal hyperreflective bands of optical coherence tomography to specific subcellular sources. Histological analysis of short post-mortem human donor eyes with age-related macular degeneration supports mitochondria, melanosomes, and lysosomes as independent reflectivity sources that can be followed longitudinally, among other discoveries available at www.projectmacula. This capability offers unprecedented opportunity both for the diagnosis and management of chorioretinal disease and the pathology component of ophthalmology training.
Referent/in: Ferdinand Schlanitz (Wien)
Referent/in: Mahdy Ranjbar (Lübeck)
Oxidative injury to the retinal pigment epithelium (RPE) has been thought to play a key role in AMD. Common household herbs, used as spices in a variety of foods, are a rich source of active antioxidant constituents. Herein, we evaluate anti-oxidative effects of various herbs with emphasis on possible molecular mechanisms of RPE rescue.
Referent/in: Martin Rudolf (Lübeck)
Referent/in: Stephan Michels (Zürich)
Intravitreal anti-Vascular Endothelial Growth Factor (VEGF) treatment has been the standard of care for neovascular age-related macular degeneration (AMD) over the past decade. Despite functional and anatomic benefits no relevant regression of choroidal neovascularization (CNV) can be obtained by such treatment. Platelet Derived Growth Factor (PDGF) inhibition bears the potential - by inhibiting pericytes – to achieve in combination with anti-VEGF treatment CNV regression and prevention of fibrosis. Several pharmaceutical companies are currently evaluating the combination of VEGF and PDGF inhibition in clinical trials for neovascular AMD. A first randomized, prospective clinical trial on neovascular AMD has shown functionally better outcomes of VEGF/PDGF inhibition compared to VEGF inhibition alone. The therapeutic concept and the status of current clinical trials are presented.