Symposien Donnerstag

Änderungen im Programmablauf vorbehalten.

Saal 1 16:15 - 17:45 01.10.2015
Symposium Do24
Ocular surface reconstruction – State of the art and future concepts
Vorsitzende/r: Thomas Armin Fuchsluger (Erlangen), Daniel Meller (Essen)

This symposium provides an extensive overview of current and upcoming strategies to treat ocular surface pathologies. This includes lid surgery, limbal and oral mucosal epithelium, new developments in biomaterials for ocular surface reconstruction and recent developments in basic science.
Referent/in: Ursula Schlötzer-Schrehardt (Erlangen)
Ocular surface reconstruction using stem cell-based therapies remains a challenging task. This may be partly related to the fact that limbal epithelial stem/progenitor cells are usually removed from their local microenvironment for ex vivo cultivation. The control of stem cell maintenance and fate has become a major area of interest in the field of regenerative medicine. This lecture provides an overview of recent developments to recreate the limbal stem cell niche, e.g. by designing biofunctional scaffolds that mimic the clues stem cells receive in their in vivo microenvironment. Such approaches have the potential to increase efficacy of stem cell transplantation for corneal surface regeneration.
Referent/in: Michela Zattoni (Modena)
Ocular surface disorders cause depletion of limbal stem cell, which lead to corneal opacification and visual loss. Cell-based therapy for limbal stem cell deficiency is a safe and effective treatment. A successful clinical application on cell therapy requires optimization of cultivation and surgical procedures, control of the microenvironment, where cells should engraft. Here, we will discuss the general principles defining rigourus criteria for graftable limbal cultures in light of their clinical performances.
Referent/in: Daniel Meller (Essen)
Besides conventional transplantation of autologous or allogeneic limbal tissue recent advances in tissue-engineering have led to the development of new culture and expansion techniques of human limbal stem and progenitor cells as a new strategy to treat successfully limbal stem cell deficiency (LSCD). Autologous grafting of cultured limbal epithelium led in most of the treated cases to a successful reconstruction of the corneal surface. The etiology of the disease causing LSCD seems to influence the outcome of the procedure. Challenges and limitations associated with stem cell culture techniques for ocular surface reconstruction will be reviewed.
Referent/in: Francisco C. Figueiredo (Newcastle upon Tyne)
Referent/in: Christoph Hintschich (München)
72 The presence of eyelid malposition (i.e entropion, ectropion, retraction) or defects, both congenital and acquired, can induce or maintain ocular surface disease. In general, any functionally relevant eyelid pathology should be corrected before performing ocular surface reconstruction. Principles and concepts for the correction of eyelid malpositions - like en- and ectropion, lid retraction, lagophthalmos - are based on the rearrangement of the normal anatomy and physiology. This includes horizontal and vertical eyelid tightening and, in case of eyelid retraction, lid lengthening procedures with or without the use of spacers. For the prevention of exposure in congenital or acquired lid defects, a whole armamentarium of procedures is available. The choice of a specific surgical procedure is very much depending on the clinical circumstances and their thorough analysis. Both indications for surgery and the principles of surgical procedures will be presented.
Referent/in: Thomas Armin Fuchsluger (Erlangen)
This talk provides insight into manufacturing of a biodegrable, biocompatible matrix for ocular surface reconstruction. The electrospinning method as well as characteristics in material selection will be presentend.