Symposien Samstag

Änderungen im Programmablauf vorbehalten.

Saal 3 14:30 - 16:00 03.10.2015
Symposium Sa22
Focus Research: German/French Meeting of the Young Investigators Network: Inflammatory diseases of the ocular surface
Vorsitzende/r: Philipp Steven (Köln), Christophe Baudouin (Paris), Johannes Schwartzkopff (Lörrach)

Inflammatory diseases of the ocular surface such as ocular allergy, dry-eye and infectious or non-infectious keratoconjunctivitis belong to the most common entities in ophthalmology. The Young Investigators Network  ( was launched in 2012 and with support by internationally renowned mentors and the Deutsche Ophthalmologische Gesellschaft currently holds 30 members in Germany, Italy and Spain forming the largest European Young Investigator Network focussing on inflammation of the ocular surface. In continuation of previous international symposia for the next DOG, we intend to invite young French investigators who focus on new strategies regarding mechanisms, diagnosis and treatment of ocular surface inflammation to further expand across inner-European boarders and to serve as a platform for new ideas, projects and collaborative science.
Referent/in: Christophe Baudouin (Paris)
Inflammation, even at a subclinical level, has been increasingly recognized as a key mechanism in ocular surface diseases, especially in dry eye disease where inflammatory cytokines induce and sustain a self-stimulated vicious circle. Inflammation is now a major hope for treating severe dry eye with anti-inflammatory strategies. The aims of this symposium are to provide the basis for better understanding dry eye disease through the scope of inflammation, to focus on newly addressed mechanisms and to identify minimally invasive techniques to identify and monitor inflammation in ocular surface diseases.
Referent/in: Antoine Labbé (Paris)
In vivo confocal microscopy (IVCM) is a noninvasive imaging technique that provides high-resolution images of the cornea, the limbus and the conjunctiva. The usefulness of IVCM to analyze ocular surface structures at a cellular level in normal and pathologic conditions has been largely demonstrated in numerous publications. IVCM actually constitutes an important aid in the diagnosis and the management of several inflammatory ocular surface diseases including dry eye disease and corneal infections, or after corneal surgery or refractive surgery.
Referent/in: Bo Jing (Köln)
Referent/in: Matthias Fuest (Aachen)
Amniotic membrane forms an essential tool in the treatment of different ocular surface diseases. The production of a wide range of anti-inflammatory factors by the amniotic epithelium, as well as other beneficial characteristics of this tissue, are discussed. Further the question is raised, whether the currently applied storage methods are suitable to preserve these beneficial properties.
Referent/in: Thabo Lapp (Freiburg)
Various inflammatory conditions can lead to cell recruitment into the anterior chamber such as acute corneal graft rejection, bacterial ulcers with hypopyon formation, or anterior uveitis. The composition of this cellular infiltrate differs as well as the clinical outcome: whereas innate immune cells in acute graft rejection lead to endothelial cell death and consecutive graft failure, cells of the adaptive immune system in anterior uveitis do not induce corneal cell death. We developed an in vitro model to simulate innate immune cell recruitment towards an inflammatory milieu enabling us to identify candidates for therapeutic targeting to inhibit monocyte / macrophage recruitment and cytopathic mechanisms for corneal endothelial injury during acute corneal graft rejection.
Referent/in: Eric Gabison (Paris)