Änderungen im Programmablauf vorbehalten.
|Saal 1||09:45 - 11:15||01.10.2015|
|Ocular GvHD - Challenge for ophthalmologists and hematooncologists|
Vorsitzende/r: Philipp Steven (Köln), Tina Dietrich-Ntoukas (Berlin)
Ocular graft-versus-host disease is a severe sight threatening entity following allogeneic blood stem cell transplantation. Until now specific risk factors, definite diagnostic parameters and causative therapeutic options are lacking. The interdisciplinary symposium brings together experts from basic and clinical science to present emerging strategies in detecting and controlling ocular GvHD under leadership of the " AG okuläre GvHD der Sektion Kornea der DOG".
Referent/in: Michael E. Stern (Irvine)
Ocular graft-versus-host disease (oGvHD) is an autoimmunological reaction following allogeneic hemato stem cell transplantation that causes severe dry-eye disease; allo-immune mediated inflammation and fibrosis of the lacrimal gland and ocular surface tissues resulting in pain, tear deficiency, photophobia, and/or vision loss. The presentation will give an overview on the current understanding of basic immunological processes, potential therapeutic strategies, and experimental models which replicate systemic and ocular forms of GVHD.
Referent/in: Daniel Wolff (Regensburg)
Chronic graft-versus-host-disease after hematopoietic stem cell transplantation (HSCT) is due to failure of central and peripheral tolerance involving allo- and autoreactive T- and B-cells, mechanisms of chronic inflammation and scarring including destruction of adnexal structures essential for regeneration and innate immunity. In ocular involvement destruction of the lacrimal glands resulting in quantitative loss and qualitative changes including loss of protective factors and increased inflammatory cytokine levels within the tear fluid, sensory neuropathy, and dysfunction of Meibomian glands play a role.
Referent/in: Philipp Eberwein (Freiburg)
Patients with ocular GvHD suffer from ocular surface inflammation causing significant glare and visual decline. Scleral lenses are a good option to improve symptoms and vision especially in these patients. Most often patients are able to manage daily life after scleral lens fit. This talk will focus on indications and follow-up of scleral lens fitting.
Referent/in: Tina Dietrich-Ntoukas (Berlin)
Ocular chronic graft-versus-host-disease (GVHD) is mainly a ocular surface disorder and can lead to severe, sight-threatening complications. The main problem are corneal complications as corneal scarring and thinning, recurrent or persistent epithelial defects, and corneal ulcers, which can lead to corneal perforation. The presentation focuses on treatment strategies in GVHD-related complications including surgical techniques.
Referent/in: Philipp Steven (Köln)
Ocular graft-versus-host disease (GvHD) is a potentially sight-threatening condition, that often requires aggressive treatment. However only few randomized prospective trials are available that provide solid evidence for lubrication, anti-inflammation, inhibition of fibrosis, etc. Also very little is known about the epidemiology of ocular GvHD which may be one of the reasons for critical shortage in patient-centered care. This presentation will give an overview on available and currently conducted clinical trials and available epidemiological data.